![]() ![]() In 2001, IHD was responsible for 7.3 million deaths and 58 million DALYs lost worldwide ( WHO 2002b). The two leading manifestations of IHD are angina and acute myocardial infarction. IHD is the single largest cause of death in the developed countries and is one of the main contributors to the disease burden in developing countries. Other causes of death, such as injuries, respiratory infections, nutritional deficiencies, and HIV/AIDS, collectively still play a predominant role in certain regions, but even in those areas CVD is now a significant cause of mortality. ![]() Nearly 50 percent of all deaths in high-income countries and about 28 percent of deaths in low- and middle-income countries are the result of CVD ( Mathers and others 2001). By 2001, CVD had become the leading cause of death in the developing world, as it has been in the developed world since the mid 1900s ( Mathers and others 20a). Murray and Lopez (1996) predicted that CVD will be the leading cause of death and disability worldwide by 2020 mainly because it will increase in low- and middle-income countries. About 80 percent of the global burden of CVD death occurs in low- and middle-income countries. At the beginning of the 20th century, CVD was responsible for less than 10 percent of all deaths worldwide, but by 2001 that figure was 30 percent. ![]()
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